منابع مشابه
Epicardium-Derived Heart Repair
In the last decade, cell replacement therapy has emerged as a potential approach to treat patients suffering from myocardial infarction (MI). The transplantation or local stimulation of progenitor cells with the ability to form new cardiac tissue provides a novel strategy to overcome the massive loss of myocardium after MI. In this regard the epicardium, the outer layer of the heart, is a tract...
متن کاملEpicardium-derived cardiac mesenchymal stem cells: expanding the outer limit of heart repair.
Adult Cardiac-Resident MSC-Like Stem Cells With a Proepicardial Origin Chong et al Cell Stem Cell. 2011;9:527–540. The epicardium is derived from the proepicardial organ, a source of multipotent progenitor cells. Epicardium contribution to the developing coronary vasculature and to cardiac interstitial cells has been established. Studies over the past several years have suggested that epicardiu...
متن کاملThymosin beta4 induces epicardium-derived neovascularization in the adult heart.
The inability of the human heart to effectively repair itself after acute ischaemic injury has driven the search for efficacious means of promoting cardiac regenerative growth. Central to this has been the emergence of cell-based strategies to stimulate and augment both myocardial regeneration and neovascularization. Autologous cell transplantation of a variety of adult progenitor cells has bee...
متن کاملEpicardium-derived cells (EPDCs) in development, cardiac disease and repair of ischemia
Reactivation of endogenous epicardium after ischemia The proepicardial-derived epicardium covers the myocardium and after a process of epithelial-mesenchymal transition (EMT) forms epicardium-derived cells (EPDCs). These cells migrate into the myocardium and show an essential role in the induction of the ventricular compact myocardium and the differentiation of the Purkinje fibres. EPDCs are fu...
متن کاملTranscriptional Control of Cell Lineage Development in Epicardium-Derived Cells
Epicardial derivatives, including vascular smooth muscle cells and cardiac fibroblasts, are crucial for proper development of the coronary vasculature and cardiac fibrous matrix, both of which support myocardial integrity and function in the normal heart. Epicardial formation, epithelial-to-mesenchymal transition (EMT), and epicardium-derived cell (EPDC) differentiation are precisely regulated ...
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ژورنال
عنوان ژورنال: Journal of Developmental Biology
سال: 2014
ISSN: 2221-3759
DOI: 10.3390/jdb2020084